Matrix metalloproteinases and their tissue inhibitors after selective laser trabeculoplasty in pseudoexfoliative secondary glaucoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN79745214

Enrollment

Registered

2008-03-20

Start date

2006-02-13

Completion date

Unknown

Last updated

2021-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pseudoexfoliative secondary glaucoma Eye Diseases Glaucoma

Interventions

Arm 1: Patients with pseudoexfoliative glaucoma with good intraocular eye pressure (IOP) control and cataract (15 patients). These patients received cataract surgery only. Arm 2: Patie

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Fifteen patients with pseudoexfoliative glaucoma and cataract, and 15 patients with pseudoexfoliative glaucoma (30 patients in total): 1. Patients of either gender 2. Aged from 58 - 74 (in all three arms)

Exclusion criteria

Exclusion criteria: 1. Pseudophachia 2. Non-pseudoexfoliative glaucoma 3. History of laser treatment

Design outcomes

Primary

Measure	Time frame
MMP-2 and TIMP-2 concentration, assessed once during the cataract surgery in Arm 1 and 3, and during trabeculectomy in Arm 2.	—

Secondary

Measure	Time frame
Intraocular pressure, measured before surgery and 7, 15 days and one month after surgery in all three arms of participants.	—

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 4, 2026