Effect of probiotic yoghurt on blood indices and intestinal microflora of healthy volunteers

Effect of probiotic yoghurt comprising L. plantarum strains TENSIA or INDUCIA on blood indices and intestinal microflora of healthy volunteers: A randomised controlled crossover trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN79645828

Enrollment

120

Registered

2010-03-18

Start date

2010-03-29

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood indices and intestinal microflora Nutritional, Metabolic, Endocrine

Interventions

The consumption once a day 150g of probiotic yoghurt vs regular yoghurt for 3 weeks. Probiotic yoghurt containing either Lactobacillus plantarum strain TENSIA or INDUCIA (10^9 colony forming units [CF

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Wish to participate in the study 2. Aged 18 years and over, both sexes 3. Healthy (i.e. no known health problems and no medical conditions that require drug therapy) 4. Signed informed consent

Exclusion criteria

Exclusion criteria: 1. History of any gastrointestinal disease 2. Use of any antimicrobial drug within last month 3. Use of any regular concomitant medication, including medical preparations 4. Food allergy 5 Pregnancy or breastfeeding

Design outcomes

Secondary

Measure	Time frame
Immunological parameters from blood will be measured by routine biochemical analyses in local clinical lab and also by Evidence investigator 1. Significantly increased circulation of polyamines in host, measured by urine gas chromotography 2. Immune stimulation (both cellular and humoral immunity)	—

Primary

Measure	Time frame
1. The health indices of study participants (body mass index, blood pressure) are assessed at the recruitment and after 3 weeks of probiotic treatment. 2. The self-reported questionnaire is applied containing questions on welfare, and habitual gastrointestinal symptoms (abdominal pain, flatulence, bloating, and stool frequency), measured once a week during the trial Fasting blood, faecal samples and morning urine will be taken at the recruitment, after 3 weeks of probiotic treatment, after washout and after placebo treatment. 3. Haematological indices will be measured by standard laboratory methods using certified assays in the local clinical laboratory (United Laboratories of Tartu University Clinics, Estonia) 3.1. Haemoglobin 3.2. White blood cell count 3.3. Red blood cell count 3.4. Platelet count 3.5. Plasma glucose 3.6. Albumin 3.7. Total cholesterol (TC) 3.8. Low-density lipoprotein cholesterol (LDL) 3.9. High-density lipoprotein cholesterol (HDL) 3.10. Triglyceride 3.11. High-sensitive C-reactive protein (hs-CRP) 3.12. Interleukin 6 (IL-6) 4. Increased counts of total faecal lactobacilli, measured by Reverse Transcriptase - Polymerase Chain Reaction (RT-PCR)	—

Measure

Time frame

1. The health indices of study participants (body mass index, blood pressure) are assessed at the recruitment and after 3 weeks of probiotic treatment. 2. The self-reported questionnaire is applied containing questions on welfare, and habitual gastrointestinal symptoms (abdominal pain, flatulence, bloating, and stool frequency), measured once a week during the trial Fasting blood, faecal samples and morning urine will be taken at the recruitment, after 3 weeks of probiotic treatment, after washout and after placebo treatment. 3. Haematological indices will be measured by standard laboratory methods using certified assays in the local clinical laboratory (United Laboratories of Tartu University Clinics, Estonia) 3.1. Haemoglobin 3.2. White blood cell count 3.3. Red blood cell count 3.4. Platelet count 3.5. Plasma glucose 3.6. Albumin 3.7. Total cholesterol (TC) 3.8. Low-density lipoprotein cholesterol (LDL) 3.9. High-density lipoprotein cholesterol (HDL) 3.10. Triglyceride 3.11. High-sensitive C-reactive protein (hs-CRP) 3.12. Interleukin 6 (IL-6) 4. Increased counts of total faecal lactobacilli, measured by Reverse Transcriptase - Polymerase Chain Reaction (RT-PCR)

—

Countries

Estonia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 6, 2026