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A trial investigating the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) for misophonia

Effect and neurophysiological mechanisms of transcutaneous auricular vagus nerve stimulation (taVNS) in misophonia: a single centre double-blinded randomised sham-controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN79500062
Enrollment
60
Registered
2025-12-09
Start date
2026-01-19
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Misophonia Signs and Symptoms

Interventions

After enrolling in the study, participants are invited to come to their first on-site visit, where they will complete baseline assessments before they are randomly allocated to receive either active t

Sponsors

University of Sussex
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Moderate to severe misophonia symptoms (scores >20 on the revised Amsterdam Misophonia Scale and scores >75 on the Sussex Misophonia Scale) 2. Not currently receiving active treatment for misophonia or planning to during the study 3. Aged between 18-40 years 4. Native English Speaker 5. Right-handed 6. No history of brain injury or neurological conditions 7. Normal or corrected to normal vision 8. Normal hearing (except for hyperacusis, tinnitus, or misophonia) 9. Owning and being willing to use a personal smartphone for tolerability questionnaires and stimulation reminders to be sent via a study app.

Exclusion criteria

Exclusion criteria: 1. Are or could be pregnant 2. Have active implants (e.g., cochlear or other metallic implant, implanted vagal nerve stimulator, cardiac pacemaker) 3. Have a cerebral shunt (e.g., for the treatment of hydrocephalus) 4. Have wounds or skin diseases at or near the ear 5. Have a history or family history of heart problems (e.g., cardiac arrhythmias) 6. Have a history of seizures or epilepsy 7. Any other contraindications to an MRI scan

Countries

England, United Kingdom

Contacts

Public ContactGiulia Poerio
g.l.poerio@sussex.ac.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 11, 2026