Cold air, physical activity and the airways

In healthy individuals, do moderate-hard physical activity in sub-zero temperature damage the airways (measured by lung function and biochemical markers)?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN79432558

Enrollment

Registered

2017-05-09

Start date

2016-09-01

Completion date

Unknown

Last updated

2021-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Airway injury Respiratory

Interventions

The study includes 60 healthy individuals, 30 in each sub-study (H7 and H8). Before the exposures, the participants perform a pre-test consisting of an incremental treadmill running protocol until exh

Therminaria

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy volunteer 2. Age 18-65 3. No allergy or asthma 4. Never regular smoker

Exclusion criteria

Exclusion criteria: 1. Asthma 2. Allergy 3. Cardiovascular disease 4. Anti-inflammatory medication 5. Regular smoker or former regular smoker 6. 65 years of age 7. Recent airway infection (<4 weeks prior to pretests and exposures)

Design outcomes

Primary

Measure	Time frame
Current primary outcome measure as of 10/06/2019: Forced expiratory volume in one second (FEV1) - a measure of lung function, assessed using dynamic spirometry and impulse oscillometry immediately before and after the exposures Previous primary outcome measure: CC16 levels, assessed using blood and urine samples taken immediately before and 60 minutes after the exposures	—

Secondary

Measure	Time frame
Current secondary outcome measures as of 10/06/2019: 1. General symptoms and symptoms of the upper and lower airways, assessed using two validated questionnaires before, during (after 10, 30 and 45 minutes), and after the exposures 2. CC16 levels, assessed using blood and urine samples taken immediately before and 60 minutes after the exposures 3. Systemic inflammatory response, assessed by taking blood samples for cell differential count immediately before and 60 minutes after the exposures Previous secondary outcome measures: 1. General symptoms and symptoms of the upper and lower airways, assessed using two validated questionnaires before, during (after 10, 30 and 45 minutes), and after the exposures 2. Lung function, assessed using dynamic spirometry and impulse oscillometry immediately before and after the exposures 3. Systemic inflammatory response, assessed by taking blood samples for cell differential count immediately before and 60 minutes after the exposures	—

Measure

Time frame

Current secondary outcome measures as of 10/06/2019: 1. General symptoms and symptoms of the upper and lower airways, assessed using two validated questionnaires before, during (after 10, 30 and 45 minutes), and after the exposures 2. CC16 levels, assessed using blood and urine samples taken immediately before and 60 minutes after the exposures 3. Systemic inflammatory response, assessed by taking blood samples for cell differential count immediately before and 60 minutes after the exposures Previous secondary outcome measures: 1. General symptoms and symptoms of the upper and lower airways, assessed using two validated questionnaires before, during (after 10, 30 and 45 minutes), and after the exposures 2. Lung function, assessed using dynamic spirometry and impulse oscillometry immediately before and after the exposures 3. Systemic inflammatory response, assessed by taking blood samples for cell differential count immediately before and 60 minutes after the exposures

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Countries

Sweden

Contacts

Public ContactLinda Eriksson

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026