Critical care Not Applicable
Conditions
Interventions
Intervention group: Essential Amino Acid supplementation given twice daily in addition to standard enteral feed.
Control group: Usual care - Standard enteral feed given according to ne
Sponsors
Imperial College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Part 1: Intensive Care Unit (ICU): Patients mechanically ventilated for > 48h High Dependency Unit (HDU): 1. Trauma patients > 18 years. 2. Patients should be entered into the trial within 72h of ICU admission. Part 2: 1. Trauma patients (head and multiple trauma) admitted to Intensive Care expected to be ventilated for > 48h 2. Over 18 years of age 3. Patients should be entered into the trial within 72 hours of ICU admission 4. Male and female participants 5. Between 18 - 95 years
Exclusion criteria
Exclusion criteria: Part 1: Patients expected to be ventilated for < 48h; Non-trauma HDU patients. Part 2: 1. Medical ICU patients 2. Surgical (non-trauma) ICU patients 3. Patients enrolled in another interventional clinical trial 4. Patients where enteral feeding is contraindicated 5. Cardiac failure 6. End Stage Renal Failure 7. Chronic Obstructive Pulmonary Disease 8. Chronic liver disease (cirrhosis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle change with a muscle ultrasound technique measured daily for 1st week, twice weekly after | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional outcomes: 1. Katz & Barthel indexes measured at day 1, 7, 14, 20 2. Indirect calorimetry measured at day 1, 5, 7, 14 3. Inflammatory markers: CRP, Albumin, cytokines measured at day 1, 5, 7, 14 4. Plasma amino acids measured at day 1, 10 5. Protein turnover with stable isotopes measured at day 1, 10, 20 6. Urinary amino acids measured at day 1, 5, 7, 14 | — |
Countries
United Kingdom
Outcome results
None listed