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Evaluation of the efficacy of irrigation with pomegranate peel extract and apple cider vinegar in disinfecting the necrotic root canals of primary teeth

In pediatric patients with necrotic primary teeth, what is the effect of irrigation with pomegranate peel extract compared to irrigation with apple cider vinegar on disinfecting the root canals

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN79064400
Enrollment
45
Registered
2023-06-02
Start date
2023-06-18
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disinfecting the necrotic root canals of primary teeth Oral Health

Interventions

A randomized double-blinded, controlled, comparative clinical study comparing the efficacy of pomegranate peel extract soaked in apple cider vinegar with sodium hypochlorite liquid and with apple cide

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Children 3-9 years old. 2. Children who have not taken antibiotics during the past 2 months. 3. The teeth (primary incisors and canines show no signs of internal radical resorption. 4. Signs of a clinically necrotic tooth with secretion of pus or fistula. 5. Radiographical transparency around the root with resorption of less than one-third of the root.

Exclusion criteria

Exclusion criteria: 1. Children who have taken antibiotics within the past two months. 2. The teeth of children with systemic diseases, in which any infection may affect the general health of the child. 3. Insufficient bony support or less than half of the root length remaining

Design outcomes

Primary

MeasureTime frame
Disinfection of the root canals is measured by counting colony-forming units (CFUs) from the cultivated samples taken from the canals before and after irrigation with each solution

Secondary

MeasureTime frame
Pain on biting measured using clinical examination at 1 week postoperatively

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026