Acute respiratory distress syndrome (ARDS) Respiratory Adult respiratory distress syndrome
Conditions
Interventions
Control group:
The FiO2-PEEP strategy has been used in previous ARDS Network studies. PEEP and FiO2 were set according to the table of lower PEEP/higher FiO2 combinations, with the goal of obtaining
Sponsors
Asan Medical Center (South Korea)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Criteria of ARDS proposed by the American-European Consensus Conference: 1.1. Acute onset 1.2. Presence of hypoxaemia (arterial oxygen tension/fraction of inspired oxygen (FiO2) (PF ratio) less than 200 mmHg regardless of the PEEP level) 1.3. Bilateral and diffuse opacities seen on frontal chest X-ray film 1.4. Absence of left ventricular failure with pulmonary arterial occluded pressure less than 18 mmHg 2. Recruited into the trial within 48 hours of meeting above ARDS criteria 3. Aged 18 - 82 years, either sex
Exclusion criteria
Exclusion criteria: 1. Haemodynamic instability 2. Elevated intracranial pressure 3. High risk of mortality within 3 months from other than ARDS (severe organ failure, and cancer patients in terminal stages of the disease) 4. Refusal to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of mechanical ventilation 2. Intensive Care Unit (ICU) stay 3. Use of paralysing or sedative agents Measured until leaving the hospital. | — |
Countries
Korea, South
Outcome results
None listed