Therapist-supervised exercise compared to usual care advice after distal radius fractures in people aged 50 years and over

Progressive resistance and flexibility exercises versus usual care advice for improving pain and function after distal radius fracture in adults aged 50 years or over: the WISE randomised superiority trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN78953418

Enrollment

588

Registered

2023-10-04

Start date

2023-11-30

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Distal radius fracture Musculoskeletal Diseases

Interventions

Participants will be randomised to one of the following groups: - Usual care advice: consisting of advice, and an information leaflet (if part of usual care) - Therapist-Supervised exercise: usual c

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patient aged 50 years or over with a distal radius fracture treated surgically or non-surgically 2. Willing and able to give informed consent for participation in the study

Exclusion criteria

Exclusion criteria: 1. Injury is more than two months old 2. There is evidence that the patient would be unable to participate in therapy or a self-guided exercise programme provided by a participating centre or adhere to trial procedures (including cognitive impairment and fracture/surgery complications such as Complex Regional Pain Syndrome) 3. Open fractures with a Gustilo & Anderson grading > 1

Design outcomes

Primary

Measure	Time frame
Wrist pain and function measured by the Patient-Rated Wrist Evaluation (PRWE) at six months post-randomisation	—

Secondary

Measure	Time frame
1. Wrist pain and function measured by the PRWE at baseline and three months post-randomisation 2. Upper extremity function measured by the PROMIS Physical Function (Upper Extremity) at baseline, three and six months post-randomisation 3. Health related quality of life measured by EuroQol 5 Dimensions EQ-5D-5L at baseline, three and six months post-randomisation 4. Confidence in ability to exercise measured by the Self-Efficacy for Exercise scale (SEE) at baseline, three and six months post-randomisation 5. Exercise adherence measured by self-reported exercise frequency at three and six months post-randomisation 6. Health resource use measured by self-reported bespoke questionnaire at three and six months post-randomisation 7. Related complications measured by patient questionnaires and site complications reporting at three and six months post-randomisation 8. Upper limb muscle strength measured by Grip Strength (cylindrical grip) at six months post-randomisation	—

Measure

Time frame

1. Wrist pain and function measured by the PRWE at baseline and three months post-randomisation 2. Upper extremity function measured by the PROMIS Physical Function (Upper Extremity) at baseline, three and six months post-randomisation 3. Health related quality of life measured by EuroQol 5 Dimensions EQ-5D-5L at baseline, three and six months post-randomisation 4. Confidence in ability to exercise measured by the Self-Efficacy for Exercise scale (SEE) at baseline, three and six months post-randomisation 5. Exercise adherence measured by self-reported exercise frequency at three and six months post-randomisation 6. Health resource use measured by self-reported bespoke questionnaire at three and six months post-randomisation 7. Related complications measured by patient questionnaires and site complications reporting at three and six months post-randomisation 8. Upper limb muscle strength measured by Grip Strength (cylindrical grip) at six months post-randomisation

—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026