Pre-treatment of deceased organ donors with methylprednisolone versus placebo for the prevention of post-ischemic acute renal transplant failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN78828338

Enrollment

200

Registered

2006-04-12

Start date

2006-03-20

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre-treatment of deceased organ donors Nutritional, Metabolic, Endocrine Prevention of post-ischaemic acute renal transplant failure

Interventions

The deceased organ donor will be randomized to receive 1000 mg of methylprednisolone or placebo three to six hours before organ retrieval. Donor kidney biopsies will be obtained before engraftment and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Deceased kidney donors

Exclusion criteria

Exclusion criteria: Non-heart beating organ donors

Design outcomes

Primary

Measure	Time frame
Incidence and duration of post-ischemic acute renal transplant failure in the transplant recipient	—

Secondary

Measure	Time frame
Genome-wide gene expression analysis of transplant kidney wedge biopsies	—

Countries

Austria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 31, 2026