Myocardial stunning during paediatric dialysis and the effects of cooling the dialystate during haemodialysis

Myocardial stunning during paediatric dialysis and the effects of cooling the dialystate during haemodialysis: a randomised interventional treatment trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN78749497

Enrollment

Registered

2010-04-29

Start date

2007-12-01

Completion date

Unknown

Last updated

2017-05-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Renal and Urogenital

Interventions

The patient will be randomised to cooled dialysate or dialysate temperature of 37ºC. Follow-up length: 24 months Study entry: single randomisation only

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Children on conventional 4 hours three times/week dialysis 2. Stable on dialysis for 2 months 3. Male and female, lower age limit of 1 month

Exclusion criteria

Exclusion criteria: Difficult echocardiogram assessments

Design outcomes

Secondary

Measure	Time frame
To determine the differences between cooled and standard dialysate in the: 1. Incidence of hypotensive episodes (IDH) defined as a blood pressure (BP) below the 5th percentile adjusted for age and sex 2. Incidence of self-reported intradialytic and postdialytic symptoms 3. Quality of the dialysis procedure based on a specific questionnaire designed to assess their treatment experience and symptoms related to feeling cold during dialysis 4. UF achieved, calculated as the ratio of actual UF volume and desired UF volume	—

Measure

Time frame

To determine the differences between cooled and standard dialysate in the: 1. Incidence of hypotensive episodes (IDH) defined as a blood pressure (BP) below the 5th percentile adjusted for age and sex 2. Incidence of self-reported intradialytic and postdialytic symptoms 3. Quality of the dialysis procedure based on a specific questionnaire designed to assess their treatment experience and symptoms related to feeling cold during dialysis 4. UF achieved, calculated as the ratio of actual UF volume and desired UF volume

—

Primary

Measure	Time frame
Regional LV dysfunction; patients will undergo echocardiogram assessments at 0, 15 and 240 minutes post-dialysis	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026