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High Intensity Exercise Training in Type 2 Diabetes

The effect of exercise on metabolism and liver lipid in people with non-alcoholic fatty liver disease (NAFLD)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN78698481
Enrollment
28
Registered
2013-01-23
Start date
2012-09-01
Completion date
Unknown
Last updated
2019-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Nutritional, Metabolic, Endocrine Non-insulin-dependent diabetes mellitus

Interventions

The exercise group will be given a high intensity exercise prescription for 3 sessions per week for 12 weeks. Each session will include 40 minutes of mainly cycling exercise in which intensity will be

Sponsors

Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged between 30-70 years old 2. Diagnosed with Type 2 Diabetes which is metformin or diet controlled 3. BMI 25-35 kg/m2 4. Take part in no regular exercise

Exclusion criteria

Exclusion criteria: 1. The absolute and relative contraindications to exercise testing as stated by the American Heart Association (Fletcher et al., 2001) 2. Taking insulin/Sulfonylurea/ TZD/ Beta-blockers 3. Contraindications for MRI scanning 4. Heart or kidney disease 5. Undergoing dietary change

Design outcomes

Primary

MeasureTime frame
Glucose control (HbA1c)—

Secondary

MeasureTime frame
1. Liver fat 2. Abdominal fat 3. Cardiac function 4. Resting and exercise metabolism (lipid oxidation) 5. Cytokine production 6. Insulin sensitivity 7. Physical Activity—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 5, 2026