Child neurology, epilepsy Nervous System Diseases Infantile spasms
Conditions
Interventions
Patients will be randomised into one of three groups:
1. ACTH 25 IU/d and 10% Glucose fluid for Venous transfusion (GV) 100 ml (continued for greater than four hours) for three weeks
2. Magnesium S
Sponsors
Beijing Children?s Hospital (China)
Eligibility
Inclusion criteria
Inclusion criteria: Primary or adjunctive therapy for infantile spasms; diagnostic criteria of International League Against Epilepsy (ILAE) greater than six spasms per day
Exclusion criteria
Exclusion criteria: 1. Patients with no infantile spasms; diagnostic criteria of ILAE greater than six spasms per day 2. Patient has one of the following infections: 2.1. Septic infections 2.2. Pneumonias 2.3. Urinary/gastrointestinal infections 2.4. Chickenpox or measles 2.5. Arterial hypertension 2.6. Electrolyte disturbances
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. EEG changes: close to normal, measured at day zero, one week, two weeks, three weeks, one month, three months and six months 2. Calcium (Ca), Magnesium (Mg) and Glucose (Glu) were measured at day zero, one week, two weeks, three weeks, one month, three months and six months 3. Neuron-Specific Enolase (NSE) levels were measured at day zero, one month, three months and six months 4. Gesell Development Scale at day zero and six months | — |
Primary
| Measure | Time frame |
|---|---|
| Seizure rate reduction: response to therapy was divided into the following categories: 29 - 0%, 69 - 30% and 99 - 70% reduction of spasms frequency as compared with baseline, and seizure-free status, respectively. | — |
Countries
China
Outcome results
None listed