Liver transplantation after preservation in brain-death organ donors Surgery Transplantation surgery
Conditions
Interventions
Aortic in situ perfusion versus aortic in situ perfusion plus arterial back-table ex situ flushing.
At the beginning of the process of abdominal dissection, a tube is placed into the
Sponsors
Johannes Gutenberg University of Mainz (Germany)
Eligibility
Inclusion criteria
Inclusion criteria: For the graft: 1. Liver graft retrieved in the Central Region of the German Foundation for Organ Transplantion (Region Mitte der Deutschen Stiftung Organtransplantation [DSO]) 2. Donor 18 - 80 years 3. Graft allocation to a participating centre For the recipient 1. Informed consent 2. Age 18 - 80 years 3. Standard criteria for liver transplantation (e.g. liver dysfunction because of cirrhosis, carcinoma)
Exclusion criteria
Exclusion criteria: For the graft: 1. Liver cirrhosis 2. Liver intoxication 3. Liver dysfunction 4. Liver trauma 5. Graft not transplantable (decision according to Standard Operating Procedures [SOP]) 6. Liver split For the recipient: 1. Standard criteria for liver transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of ITBL six months after transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rate of ITBL or death within six months after transplantation 2. Parenchymal function following transplantation 3. Documentation and analysis of adverse events All secondary outcomes are measured within six months after transplantation. | — |
Countries
Germany
Outcome results
None listed