Nutritional, Metabolic, Endocrine: Hyperglycaemia Nutritional, Metabolic, Endocrine Hyperglycaemia
Conditions
Interventions
Intervention: Insulin aspart (NovoNordisk) for intravenous injection. Insulin will be given intravenously at a fixed rate of 0.05 u/kg/hour. It will be prepared as a standard strength solution of 25 u
Sponsors
Cambridge University Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Birth weight <1500 g 2. Requiring intensive care and in whom it is considered appropriate to continue intensive care 3. Less than 24 hours of age 4. Written informed parental consent
Exclusion criteria
Exclusion criteria: 1. Maternal diabetes including gestational diabetes 2. Babies where the appropriateness of continuing intensive care is being discussed 3. Major congenital anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death on or before expected date of delivery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Episodes of sepsis in the first 2 weeks 2. Growth 3. Incidence of necrotizing enterocolitis 4. Retinopathy of prematurity 5. Incidence of intracranial haemorrhage 6. Chronic lung disease 7. Death within and including the first 28 days after delivery 8. Days of Neonatal Intensive Care | — |
Countries
Belgium, Netherlands, Spain, United Kingdom
Outcome results
None listed