Topic: Cardiovascular, Neurological
Conditions
Interventions
Control arm:
Uninflated blood pressure cuff will be placed on the patients's upper arm for the duration of 30 minutes.
Intervention arm:
Inflation of a blood pressure cuff placed around the upper arm
Sponsors
University College London (UCL) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing percutanous coronary interventions in the elective and emergecy setting and patients undergoing thrombolysis for acute myocardial infarction 2. Aged greater than 18 years and less than 85 years 3. Male and female patients
Exclusion criteria
Exclusion criteria: 1. Aged less than 18 years and greater than 85 years 2. Patients with severe renal impairment (estimated glomerular filtration rate [EGFR] less than 45 ml/min/1.73m2) 3. Patients with severe hepatic impairment 4. Patients with cardiac arrest in the previous 6 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial injury, measured by cTnT and CK-MB release over 24 hours after PCI. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. All-cause mortality, recurrence of symptoms, heart failure and hospitalisation at 1 year after primary percutaneous coronary intervention (PCI) 2. Major adverse cardiovascular events (MACE) at 1 year 3. Myocardial infarct size, 3 months after primary PCI as measured by cardiac magnetic resonance imaging (MRI) 4. Myocardial infarct size and myocardial salvage ratio (infarct size/area at risk) as measured by cardiac MRI | — |
Countries
United Kingdom
Outcome results
None listed