Dementia with Lewy bodies, Parkinson's disease dementia, Alzheimer's dementia, vascular dementia, frontotemporal lobe dementia Mental and Behavioural Disorders Dementia
Conditions
Interventions
A double blind crossover trial will compare instant coffee (a cup containing 1 standard sachet of approximately 4g Starbucks VIA Ready Brew Italian Roast with 250ml of hot water) with decaffeinated in
Sponsors
North Bristol NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with dementia with Lewy bodies or Parkinson's disease dementia fulfilling standard diagnostic criteria who retain capacity to consent to research, in keeping with the Mental Capacity Act 2005 2. Patients on or off cholinesterase inhibitors or memantine as long as stable on medication for 3 months or more 3. An adequate level of communication in written and verbal English
Exclusion criteria
Exclusion criteria: 1. Patients with alternative neurodegenerative diseases or other condition likely to interfere with test performance (e.g. chronic pain, stroke) 2. Patients on medication likely to interfere with cognitive performance that has been changed in the last 3 months 3. The tests of attention in this trial require a working knowledge of English, good vision and the ability to walk independently (with or without walking aids) and we will therefore exclude patients without sufficient English language skills, those with poor vision and those who cannot walk independently. 4. Patients taking caffeine containing medication or foodstuffs with greater than 15mg caffeine over a day who do not wish to cease ingestion 5. If a patient loses capacity to consent during the trial they will be withdrawn
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Attention, measured by neuropsychological tests | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ability to complete a timed walk 2. Ability to complete a timed walking while talking task 3. The measure of habitual caffeine intake by patients with dementia and its correlation with hallucinations and sleeping patterns | — |
Countries
United Kingdom
Outcome results
None listed