Alcohol and opioid use disorder Mental and Behavioural Disorders
Conditions
Interventions
Following neurosurgical implantation, deep brain stimulation (DBS) will be delivered at chronic high frequency (~130 hz
2-4 V) in the nucleus accumbens and ventral internal capsule. The stimulation protocol parameters will be optimized over the 6-month open-label stimulation optimization period. At postoperative month
Sponsors
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of treatment-refractory opioid use disorder (OUD) or alcohol use disorder (AUD) (DSM-5 diagnosis) 2. Comorbid nicotine dependence, other psychoactive use disorder permissible as long as OUD or AUD is the primary diagnosis 3. At least 5 years duration 4. 3+ failed abstinence attempts 5. Failed psychotherapy and standard pharmacotherapy 6. Age 18 to 60 years old 7. MRI compatible 8. Capable of informed consent
Exclusion criteria
Exclusion criteria: 1. Deep brain stimulation or neurosurgical contraindication (e.g. unable to tolerate general anaesthesia, risk of bleeding) 2. History of repeated falls 3. Other major psychiatric (e.g. schizophrenia, bipolar disorder or severe major depression) or neurologic disorder 4. Major head injury 5. Marked cognitive impairment or cortical atrophy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alcohol and opioid use is measured using Timeline Followback during randomised control cross-over trial at baseline and months 1, 2, 3 and 4 | — |
Secondary
| Measure | Time frame |
|---|---|
| Alcohol and opioid use is measured using Timeline Followback during open-label stimulation optimisation at baseline and months 1, 2, 3, 4, 5, 6 | — |
Countries
England, United Kingdom
Contacts
Public ContactValerie;Samantha Voon;Sallie
;
Outcome results
None listed