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Acetic-acid enhanced colonoscopy for the increase of polyp detection

Prospective randomized comparison of acetic-acid assisted colonoscopy versus standard wight-light colonoscopy in the detection of sessile serrated adenomatous (SSA) lesions in the right colon

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN78002736
Enrollment
400
Registered
2019-09-21
Start date
2019-07-01
Completion date
Unknown
Last updated
2019-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal polyps detected by colonoscopy Digestive System Polyp of colon

Interventions

Patients who are scheduled for screening, surveillance or diagnostic colonoscopy will be recruited to the study and randomised to one of two groups. Each enrolled subject will undergo two "back-to-bac

Sponsors

General Hospital of Nikaia-Piraeus "Agios Panteleimon"
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The patient is undergoing colonoscopy for screening, for surveillance in the follow-up of the previous polypectomy or for diagnostic workup. 2. The patient must understand and provide written consent for the procedure.

Exclusion criteria

Exclusion criteria: 1. History of colonic resection. 2. Inflammatory bowel disease. 3. Personal history of a polyposis syndrome. 4. Suspected chronic stricture potentially precluding complete colonoscopy. 5. Diverticulitis or toxic megacolon. 6. History of radiation therapy to abdomen or pelvis. 7. Ulcer of the rectum. 8. Ischemic colitis or intestinal ischemia. 9. Inadequate bowel preparation (BBPS 3-6).

Design outcomes

Primary

MeasureTime frame
The additional number of sessile serrated adenomatous (SSA) lesions detected at the level of the right colon after spraying of acetic acid and compared with the number of the same lesions detected after a second examination of the right colon using standard white-light high definition scopes and solution without acetic acid.

Secondary

MeasureTime frame
Measured as numbers of the events and the polyps detected through the examinations: 1. Number of new serrated lesions detected at second right colon examination in both studies group. 2. Number of overall serrated and/or adenomatous lesions in the whole colon. 3. Characteristic of lesions detected (size, morphology). 4. Complication rate.

Countries

Greece

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026