Urological and Genital Diseases Urological and Genital Diseases
Conditions
Interventions
The investigations will comprise the following:
Sperm Storage
Immediately on referral, patients will be given the opportunity to have spermatozoa cryopreserved at the ACU, Birmingham Women's Hospital
motility
antisperm antibodies. vitality are carried out in accordance with the World Health organisation (WHO, 1992). Computer assisted sperm motility analysis (CASA) will also be performed, using an Hamilton
1998) Mitochondrial DNA fragmentation will be studied using long PCR according to the methods of St.John, (in press).
Mitochondrial Function
Mitochondrial membrane potential will be assessed using th
Sponsors
Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Patients will be referred from tertiary referral centres in Birmingham. These will include principally the Queen Elizabeth Hospital in Edgbaston, Selly Oak Hospital and the Dept of Haematology, Heartlands Hospital. They will have been referred for sperm storage to prior to chemo or radiotherapy mainly in cases of malignant disease but also in other conditions e.g. treatment of nephrotic syndrome. Patients will be randomised to treatment groups at the point of intention to treat.
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed