Serotonin regulation of the human stress response

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN77876347

Enrollment

Registered

2005-05-10

Start date

2005-04-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress/Anxiety Mental and Behavioural Disorders Reaction to severe stress, and adjustment disorders

Interventions

1. Tryptophan depletion, double-blind crossover with Tryptophan restored intervention 2. Single breath 35% CO2 inhalation single blind crossover with single breath room air

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers aged 18-65 2. Able & willing to give informed consent prior to participation

Exclusion criteria

Exclusion criteria: Any psychiatric morbidity by GP report, psychiatric clinical interview, or MINI v5 (Sheehan et al. 1998) semi-structured interview

Design outcomes

Primary

Measure	Time frame
Visual Analogue rating Scales (VAS), The Spielberger State Anxiety Inventory (STAI), Cortisol & tryptophan levels.	—

Secondary

Measure	Time frame
The Panic Symptom Inventory (PSI), Prolactin levels, Blood pressure/heart rate data, Swedish universities Scales of Personality (SSP)	—

Countries

Australia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026