Cardiovascular risk factors Circulatory System
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Men and women between 25 and 65 years of age 2. Healthy as assessed by a physician 3. Body mass index (BMI) greater than or equal to 20 and less than or equal to 31 kg/m^2 4. Plasma low density lipoprotein cholesterol (LDL-C) greater than or equal to 3.5 mmol/l 5. Haemoglobin (Hb) greater than or equal to 120 g/l for women and greater than or equal to 130 g/l for men
Exclusion criteria
Exclusion criteria: 1. Participation in a clinical study within 90 days prior to screening visit and throughout the study 2. Use of lipid lowering drugs two months prior screening and throughout the study 3. Blood pressure greater than 145/85 mmHg 4. Use of products or supplements fortified with plant sterols, omega-3, omega-6 or omega-9 fatty acids within 3 weeks prior to baseline visit 5. Allergy to certain foods 6. Weight-loss diets or drugs 7. Special diets (e.g. vegan and gluten free) 8. Pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in plasma LDL-C after 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in: 1. Other blood lipids and apolipoproteins 2. Blood pressure 3. Insulin sensitivity (fasting insulin and homeostatic model assessment insulin resistance [HOMA-IR]) | — |
Countries
Sweden