Acute renal failure after SIRS/septic shock Urological and Genital Diseases Renal failure
Conditions
Interventions
Continuous venovenous haemodialysis treatment with high-flux or high-cut-off dialysers.
Please note that as of 13/12/2007 the anticipated end date of this trial was extended to 31/12/
Sponsors
Gambro Dialysatoren GmbH (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Fulfilling at least two of the SIRS criteria as defined by the American College of Chest Physicians (ACCP)/Society of Critical Care Medicine (SCCM) Consensus Conference 2. Having signs of renal dysfunction 3. Requirement for catecholamine administration (norepinephrine or others) 4. Acute Physiology And Chronic Health Evaluation (APACHE II) score at enrolment greater than or equal to 19 and less than or equal to 30
Exclusion criteria
Exclusion criteria: 1. Lack of written informed consent from patients or a legally authorized surrogate 2. Duration of septic shock greater than 4 days 3. Hypoproteinaemia (characterized by serum albumin less than 18 g/l) 4. End stage renal failure 5. Known active malignancy 6. Known human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infection 7. Age younger than 18 years or older than 80 years 8. Known pregnancy 9. Immunosuppression after transplantation 10. Participation in another clinical study 11. Renal replacement therapy greater than 24 hours before randomisation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Dosage of vasopressors 2. Mean arterial pressure 3. Heart rate 4. Central venous pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Sequential Organ Failure Assessment (SOFA) score 2. Survival at 28 days 3. Length of need for catecholamine application 4. Length of need for mechanical ventilation 5. Length of need for renal replacement therapy 6. Length of stay in intensive care unit (ICU) | — |
Countries
Austria, Germany
Outcome results
None listed