Age related inflammation and DNA methylation Other
Conditions
Interventions
This trial will test the hypothesis that a combination of vitamins and nutraceuticals (“Essentials”), all known to have an effect on immune ageing or systemic inflammation will improve both biological
Sponsors
University of Birmingham
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age =60 years. 2. Ability to provide informed consent. 3. Willing to stop taking multivitamins, and dietary supplements containing vitamins C and D, B3, DHA/EPA, Olive polyphenols, resveratrol and astaxanthin or food/beverage products supplemented with the above ingredients 2 weeks prior to and throughout the study. 4. Able to travel to the clinic for initial and subsequent evaluations.
Exclusion criteria
Exclusion criteria: 1. Current smokers, or ex smokers who have stopped within the last 12 months, or are using nicotine replacement products. 2. History of diabetes, myocardial infarction, congestive heart failure, kidney failure, liver disease or stroke. 3. Untreated thyroid disorder, cancer, active neoplasms. 4. Untreated gastrointestinal, or pulmonary diseases. 5. Surgery or trauma in last 60 days. 6. Inflammatory diseases, auto immune diseases or recent infection in last 60 days. 7. Allergies to any of the ingredients to be studied. 8. Currently taking or using multivitamins or dietary supplements containing vitamins C and D, B3, DHA/EPA, Olive polyphenols, resveratrol and astaxanthin or food/beverage products supplemented with the above ingredients. 9. Currently taking medication known to be metabolised by CYP3A. 10. Currently taking any of the following medications, which confound the effects of inflammation: Tamoxifen, Cyclosporine A, immunosuppressants or Anti TNF inhibitors, NSAIDs. 11. Currently taking any of the following anticoagulant drugs (blood thinners): Warfarin, Direct oral anticoagulant drugs (DOACs), and antiplatelet drugs including aspirin. 12. Individuals at risk of bleeding complications, including those with inherited bleeding disorders (such as haemophilia), or increased risk hemorrhagic stroke or events. 13. Unable or unwilling to maintain current lifestyle throughout study such as eating habits, exercise habits, etc. 14. Assessed as being frail by Fried phenotype criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune ageing by measuring 51 different serum cytokines, chemokines and growth factors to give an iAGE score (Sayed et al 2021), hs-CRP will also be measured at baseline and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| At baseline and 12 weeks we will measure 1. Biological ageing by DNA methylation in peripheral blood and saliva; 2. QoL (SF36) and diet (7 day food diary, to confirm there was no significant change in the diet of the participants) from questionnaires; 3. Physical function assessed by the SPPB (Guralink et al. 1994). | — |
Countries
England, United Kingdom
Contacts
Public ContactThomas Jackson
Outcome results
None listed