Analgesia in wisdom tooth extraction Signs and Symptoms Analgesia
Conditions
Interventions
Participants will be randomly assigned to either:
1. Oral pre-med group: two 500 milligram paracetamol capsules and 100 ml bag of normal saline for injection, or
2. IV group: two placebo lactose caps
Sponsors
Queen Victoria Hospital NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients over 18 years (either sex) having a general anaesthetic for extraction of wisdom teeth of which at least one must be a lower molar tooth.
Exclusion criteria
Exclusion criteria: 1. Patients who are unable to give full consent, or who do not wish to take part in the trial 2. Patients who have a baseline Visual Analogue Scale (VAS) score of more than zero 3. Patients unable to swallow tablets 4. Patients who have taken simple analgesics that day, prior to surgery 5. Hypersensitivity or history of serious adverse reactions to paracetamol or non-steroidal anti-inflammatory drugs 6. Active liver disease 7. Renal dysfunction 8. Pregnant or breast feeding women 9. Alcohol or drug abuse 10. History of unresponsiveness to paracetamol 11. Gastric or peptic ulcer disease 12. Inflammatory bowel disease 13. Blood coagulation abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will compare the pain scores of patients in the two study arms one hour post-operatively. This will be done in recovery using a Visual Analogue Scale (VAS) pain scoring system. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will compare the time to request of post-operative ?rescue? analgesia between the two study arms. Specifically, this will be measured from when the patient arrives in recovery. This point will serve as a standard ?time zero? (t0). The time elapsed before the patient requests additional analgesia (if at all) will act as a secondary surrogate marker of analgesic efficacy. | — |
Countries
United Kingdom
Outcome results
None listed