Evaluation of the efficiency of autologous albumin gel mixed with I-PRF and artificial bone graft in alveolar ridge preservation following tooth extraction

Evaluation of the efficiency of autologous albumin gel mixed with I-PRF and artificial bone graft in alveolar-ridge-preservation following tooth extraction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN77480970

Enrollment

Registered

2024-06-20

Start date

2023-02-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symmetrical teeth indicated for extraction Oral Health

Interventions

The study aims to compare two different treatments for maintaining alveolar bone dimensions after tooth extraction. On one side, autologous albumin gel mixed with platelet-rich fibrin (PRF) and artifi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. There are no general diseases 2. There is no periodontitis 3. There is no contraindication for local anesthesia or oral surgery 4. Extraction socket type 1 according to Elian, 2007

Exclusion criteria

Exclusion criteria: 1. Pregnant and breastfeeding 2. The presence of an acute abscess or vestibular fistula in the work area 3. Smoker patient 4. Alcoholics 5. Taking medications that affect bone metabolism

Design outcomes

Primary

Measure	Time frame
1. Radiographic Bone Density: ROI Region of Interest By drawing a rectangle in the extraction socket in the image taken six months after the alveolar ridge preservation procedure and recording the average value given, measured using the Ez3Di viewer program 2. Study of changes in alveolar bone dimensions: The two images are uploaded to the OnDemand3D program. We perform matching in the three axes - sagittal, frontal, and vertical - and then choose the appropriate section of the image in which the surgical intervention was performed. 3. Measuring vertical changes (alveolar ridge height): A line is drawn that connects the top of the vestibular plate to the top of the lingual or palatal plate, and from the middle of this line a line is drawn to the height of the socket. In this way, the vertical height of the socket is measured immediately after the extraction and six months after the extraction, and the amount of change that occurs is calculated after that. 4. Measuring horizontal bone changes (width of the alveolar ridge): Two horizontal lines are drawn at level 3 and level 5 mm from the edge of the alveolar bone on the image taken immediately after the extraction. These lines are fixed when measuring on the second image (six months later) after merging the two images together, and the amount is then calculated. The change is happening.	—

Measure

Time frame

1. Radiographic Bone Density: ROI Region of Interest By drawing a rectangle in the extraction socket in the image taken six months after the alveolar ridge preservation procedure and recording the average value given, measured using the Ez3Di viewer program 2. Study of changes in alveolar bone dimensions: The two images are uploaded to the OnDemand3D program. We perform matching in the three axes - sagittal, frontal, and vertical - and then choose the appropriate section of the image in which the surgical intervention was performed. 3. Measuring vertical changes (alveolar ridge height): A line is drawn that connects the top of the vestibular plate to the top of the lingual or palatal plate, and from the middle of this line a line is drawn to the height of the socket. In this way, the vertical height of the socket is measured immediately after the extraction and six months after the extraction, and the amount of change that occurs is calculated after that. 4. Measuring horizontal bone changes (width of the alveolar ridge): Two horizontal lines are drawn at level 3 and level 5 mm from the edge of the alveolar bone on the image taken immediately after the extraction. These lines are fixed when measuring on the second image (six months later) after merging the two images together, and the amount is then calculated. The change is happening.

—

Secondary

Measure	Time frame
Pain is measured using a visual analogue scale (VAS) at baseline 24, 48, and 72 h	—

Countries

Syria

Contacts

Public ContactZain Moalla

zainmoalla150@gmail.com+963 94758006

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026