Multiple sclerosis Nervous System Diseases Multiple sclerosis
Conditions
Interventions
We will capture retinal images from consenting patients with MS and also healthy volunteers . We will identify candidate retinal biomarkers that could stratify MS patients, act as early indicators of
Sponsors
University of Edinburgh (UK)
NHS Lothian (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Competent and consenting adults between the ages of 18 and 75 years 2. Patients with MS including those with clinically isolated syndrome, relapse-remitting, secondary progressive and primary progressive - 25 in each group 3. Participants must be able to manoeuvre themselves to the retinal imaging room in the Rowling Clinic unaided, sit upright in a chair or wheelchair, comfortably position themselves for imaging, and be able to listen to and act upon directions for fixing their gaze
Exclusion criteria
Exclusion criteria: 1. People who cannot manoeuvre themselves to the retinal imaging room in the Rowling Clinic unaided, who cannot sit upright in a chair or wheelchair, who cannot comfortably position themselves for imaging, or who would struggle with listening to or acting upon directions for fixing their gaze 2. People under the age 18 or over the age of 75
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in retinal structure and function as measured by computation analysis of imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual acuity (full contrast and reduced contrast), refractive error (from glasses or focimeter or refraction), and expanded disability status scale (EDSS). Correlation will be made with information on diagnosis, subtype, date of onset of symptoms, date of diagnosis, history of optic neuritis, history of other eye diseases, and any current visual symptoms. This will include phenotypic description, disease metric correlation, and integration of retinal image measurements into a combined score. | — |
Countries
United Kingdom
Outcome results
None listed