Neonatal nutritional supplementation Neonatal Diseases
Conditions
Interventions
Infants randomised to one of two groups receiving either Nutriprem A or B, one without and one with 0.8 g GOS/FOS oligosaccharides /dl, to make up any shortfall in their own mother?s milk or as sole d
Sponsors
Milupa GmbH, Numico Research (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Preterm infants, appropriately grown for gestational age, with a gestational age =32 + 6 weeks (days), whose mothers agree to the use of formula if they are unable to or do not wish to breast feed or are not able to provide sufficient breast milk
Exclusion criteria
Exclusion criteria: 1. More than 72 hours exclusive parenteral nutrition 2. Immediately life-threatening congenital abnormality 3. Any condition requiring major surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Number of days from birth to reach a total (sole formula or formula with breast milk) daily enteral intake of 150 ml/kg 2. Number of days between birth and 28 days that a total (sole formula or formula with breast milk) daily enteral intake of at least 150 ml/kg is tolerated | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Gain in weight, length and head circumference 2. Faecal flora 3. Faecal calprotectin 4. Faecal characteristics 5. Gastrointestinal tolerance 6. Fluid balance 7. Necrotising enterocolitis 8. Bloodstream infection | — |
Countries
United Kingdom
Outcome results
None listed