Decreased copper status Nutritional, Metabolic, Endocrine Nutritional deficiencies
Conditions
Interventions
Each boy (25 per group) will take two zinc tablets per day (one in the morning with breakfast and one in the evening with dinner) for 120 days that will provide a total of either 0 (placebo group), 5,
Sponsors
Health Canada (Canada)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Healthy boys 7 to 8 years of age 2. Boys not taking a mineral supplement and have not taken a mineral supplement three months prior to commencing the study 3. Boys not taking sodium fluoride or aspirin 4. Boys living in Guelph, Ontario vicinity 5. Informed consent by the caregivers of the boys 6. Assent by the boys
Exclusion criteria
Exclusion criteria: Individuals not fulfilling the above inclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects of different levels of zinc intake on copper status will be determined by measuring the following indices of copper nutriture: 1. Expression of erythrocyte copper chaperone for Cu/Zn superoxide dismutase 2. Plasma copper concentration 3. Plasma ceruloplasmin activity 4. Erythrocyte Cu/Zn superoxide dismutase activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Effects of different levels of zinc intake on: 1. Height 2. Weight 3. Complete blood counts 4. Lipid profile | — |
Countries
Canada
Outcome results
None listed