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Comparison of the efficacy of pimecrolimus 1% cream and hydrocortisone 1% cream in facial seborrheic dermatitis: a single-blind randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN77370654
Enrollment
40
Registered
2005-04-19
Start date
2005-01-20
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Seborrheic dermatitis Skin and Connective Tissue Diseases Dermatitis

Interventions

Group 1: pimecrolimus 1% cream applied twice daily for 2 weeks Group 2: hydrocortisone acetate 1% cream applied twice daily for 2 weeks

Sponsors

Tehran University of Medical Sciences (Iran) - Center for Research and Training in Skin Diseases and Leprosy
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with facial seborrheic dermatitis older than 8 years.

Exclusion criteria

Exclusion criteria: 1. Presence of active malignancy on the facial lesion 2. Presence of any kind of active viral skin disease on the facial lesion 3. Use of oral steroids in the past two weeks 4. Use of psoralen plus ultraviolet A (PUVA), ultraviolet B (UVB), ultraviolet A (UVA), azathioprine or cyclosporin in past month 5. Application of any topical treatment in past week 6. Use of any systemic antibiotics or antifungals in past 2 weeks 7. Attending in any other research study

Design outcomes

Primary

MeasureTime frame
1. Clinical response (erythema, pruritis, scaling) at 2, 4 and 6 weeks after treatment 2. Patient's general perception about treatment result 3. Adverse events in each treatment group

Secondary

MeasureTime frame
Not provided at time of registration

Countries

Iran

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026