Diabetic nephropathy, renal structural changes Nutritional, Metabolic, Endocrine Diabetes
Conditions
Interventions
Thirty type 2 diabetic patients showing either normoalbuminuria or microalbuminuria participated. Microscopic morphometric analyses provided quantitative glomerular structural changes. Patients were
Sponsors
Kitasato University School of Medicine (Japan)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Normotensive type 2 diabetic patients 2. Without overt proteinuria, haematuria or renal dysfunction 3. Without any evidence suggesting atherosclerotic diseases 4. Living kidney donors served as healthy controls 5. Aged 20 - 65 years, either sex
Exclusion criteria
Exclusion criteria: 1. Receiving antihypertensive drugs 2. With a past history of any malignant, cerebrovascular or cardiovascular disease 3. With recurrent infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The GFR measured by the plasma clearance of unlabeled iohexol. The plasma concentration of iohexol was measured by HPLC. Measured every 6 months after renal biopsy. | — |
Secondary
| Measure | Time frame |
|---|---|
| The urinary albumin measured by turbidimetric immunoassay. Measured every 6 months after renal biopsy. | — |
Countries
Japan
Outcome results
None listed