A study of radiotherapy with or without chemotherapy in primary central nervous system (CNS) lymphoma

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN77275134

Enrollment

Registered

2001-02-28

Start date

1988-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Cancer Lymphoma

Interventions

Group 1: radiotherapy alone (54 Gy total dose in 27 fractions) Group 2: radiotherapy as above, followed after 4 weeks by six cycles of CHOP chemotherapy given at 3-week intervals (cyclophosphamide 750

Eligibility

Inclusion criteria

Inclusion criteria: 1. Pathologically proven primary cerebral lymphoma 2. Aged 18-75 3. No previous radiotherapy or chemotherapy 4. Adequate neurological, physical and mental function

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Survival.	—

Secondary

Measure	Time frame
Event-free survival.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026