Coronary heart disease Circulatory System Coronary heart disease
Conditions
Interventions
Comparing non-invasive techniques for diagnosing coronary artery disease (ETT, SPECT and CMR) against invasive angiography. Patients who agree to take part in the study will initially undergo three in
Sponsors
British Heart Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Ages between 35 and 79 years 2. Weight less than 110 kg 3. Suitable for coronary revascularisation if required 4. Clinically stable 5. In sinus rhythm
Exclusion criteria
Exclusion criteria: 1. Previous revascularisation 2. Evidence of crescendo angina or acute coronary syndrome 3. Contraindication to MRI imaging (pacemaker, intraorbital debris, intraauricular implants, intracranial clips) 4. Contraindication to adenosine infusion (regular adenosine antagonist medication, asthma/chronic obstructive pulmonary disease, second or third degree atrioventricular heart block, sino-atrial disease) 5. Aged less than 35 years 6. Weight greater than 100 kg 7. Non-sinus rhythm 8. Resting heart rate greater than 100 /min 9. Frequent ventricular ectopy (greater than 3 Ventricular Premature Beats [VPB] per minute) 10. Pregnancy 11. Known adverse reaction to adenosine or gadolinium contrast agent 12. Inability to lie supine for 60 minutes 13. Known chronic renal insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The diagnostic performance of MRI to detect significant CHD on x-ray angiography | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The diagnostic performance of current standard clinical investigations of ETT and SPECT 2. The cost effectiveness of CMRI in a diagnostic strategy for the systematic investigation of patients with suspected CHD 3. Patient's preference of the different strategies for the investigation of suspected CHD | — |
Countries
United Kingdom
Outcome results
None listed