Osteoporosis Musculoskeletal Diseases Osteoporosis
Conditions
Interventions
Group 1: exercise training plus isoflavone placebo
Group 2: exercise training placebo (flexibility program) plus isoflavone therapy
Group 3: exercise training plus isof
Sponsors
University of Saskatchewan (Canada)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Post-menopausal women (age range of approximately 45 to 70 years)
Exclusion criteria
Exclusion criteria: 1. Diagnosed osteoporosis 2. Previous fragility fractures 3. Above normal bone mineral density (equal to or above the young adult mean) 4. Breast or endometrial cancers 5. Women taking bisphosphonates, hormone replacement therapy, selective estrogen receptor modulators, parathyroid hormone (PTH), or calcitonin in the past 12 months 6. Taking corticosteroids or diuretics 7. Diagnosed Crohn?s Disease and Cushing Disease 8. Women with allergies to soy 9. Severe osteoporosis 10. Smokers 11. Currently participating in vigorous exercise programs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lumbar spine bone mineral density | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Bone mineral density of the proximal femur and whole body 2. Bone quality of the calcaneus 3. Geometry the proximal femur 4. Lean tissue mass 5. Fat mass 6. Body mass index 7. Waist girth 8. Skinfolds 9. Blood lipids 10. Breast density 11. Endometrial thickness 12. Menopausal symptoms 13. Physical activity levels 14. Muscular strength 15. Self-paced walking ability 16. Balance and flexibility | — |
Countries
Canada
Outcome results
None listed