Experimentally induced itch in healthy subjects Signs and Symptoms
Conditions
Interventions
Participants visit Leiden University once for approximately 4.5 hours. Expectations regarding itch stimuli are induced by conditioning and verbal suggestion procedures with respect to purple and yello
Sponsors
Leiden University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy human volunteers 2. 18 - 35 years old 3. Both male and female 4. Fluent in Dutch language
Exclusion criteria
Exclusion criteria: 1. Severe morbidity (e.g., multiple sclerosis, diabetes mellitus, heart or lung diseases) 2. Psychiatric disorders (e.g., depression) 3. Use of pacemaker 4. Color blindness 5. Diagnose of histamine hypersensitivity 6. Chronic itch or pain complaints 7. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of itching, measured using an NRS score, induced by each electrical stimulus | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Scratching behavior, induced by each electrical stimulus. Scratching behaviour is assessed by videotaping the participants during the experiment. Frequency, duration and localization of scratching behaviour are scored by an experimenter who is blinded for the randomization of groups and colored cues. 2. Level of itching (NRS rating) and scratching behavior induced by histamine iontophoresis | — |
Countries
Netherlands
Outcome results
None listed