Post-operative morbidity Surgery Morbidity
Conditions
Interventions
Patients randomised to undergo fluid with/without inotropic support (goal-directed therapy) to achieve pre-defined oxygen delivery target for 6 hours immediately post-operatively.
Sponsors
University College London Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing major elective major surgical procedures that are associated with a high incidence of post-operative morbidity (abdominal/oesophageal/hepatic resection/gynaecology/urological reconstructive surgery) and who meet the following criteria: 1. American Society of Anaesthesiologists risk grade 3 - 4 2. Aged greater than 50 years, either sex 3. Greater than two risk factors defined by the Revised Cardiac Risk Index
Exclusion criteria
Exclusion criteria: 1. Concurrent lithium therapy (incompatible with cardiac output monitoring device) 2. Acute myocardial ischaemia (contraindication for inotropic support) 3. Acute arrhythmias (contraindication for inotropic support) 4. Pregnancy (lithium-based cardiac output monitoring device) 5. Patients receiving palliative treatment only
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in post-operative morbidity on day 3 post-operatively as defined by the Post-Operative Morbidity Survey (POMS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured pre-operatively and at 1, 2, 5 and 8 days post-operatively: 1. Immune, bioenergetic, microcirculatory and cellular correlates associated with development of post-operative morbidity 2. Length of hospital stay | — |
Countries
United Kingdom
Outcome results
None listed