Bowel surgery influences body's water, electrolyte and sugar control

Metabolic consequences following colectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN76735966

Enrollment

150

Registered

2013-03-21

Start date

2011-12-05

Completion date

Unknown

Last updated

2021-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic disturbances following colectomy Surgery

Interventions

Part 1 (Observational study) Experimental design: To measure indices of sodium intake (diet diary), sodium loss (urine Na+, K+, plasma aldosterone) and insulin resistance (insulin, glu

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants who have undergone IRA or RPC or colectomy with ileostomy 2. Surgery >1 year previously, or preoperative patients (part 3) 3. Absence of small bowel disease, Crohn's, Coeliac disease etc 4. No recent use of steroid medication (< 1 year) 5. 18 < BMI < 30 kg/m2 6. Minimal small bowel resection (<10 cm) 7. Aged 14-70 years

Exclusion criteria

Exclusion criteria: 1. Patients with diabetes 2. Patients who are unwilling to consent 3. Patients who are regularly taking the electrolyte mix 4. Patients with any known adrenal gland disorder

Design outcomes

Primary

Measure	Time frame
To determine how prevalent sodium depletion and hyperaldosteronism are in well adapted patients following ileorectal anastomosis (IRA) or restorative proctocolectomy (RPC) or colectomy with ileostomy.	—

Secondary

Measure	Time frame
1. To determine if sodium depletion in well adapted patients following IRA or RPC or colectomy with ileostomy is associated with and causative of abnormal glucose tolerance. 2. To ascertain if these metabolic changes can be reversed with a simple rehydration therapy which could be easily incorporated into patient aftercare. 3. To ascertain if these metabolic changes can be prevented from developing post-operatively with a simple rehydration therapy which could be easily incorporated 4. Differences in health-related quality of life scores as assessed using SF-36 and FACIT- F questionnaires	—

Measure

Time frame

1. To determine if sodium depletion in well adapted patients following IRA or RPC or colectomy with ileostomy is associated with and causative of abnormal glucose tolerance. 2. To ascertain if these metabolic changes can be reversed with a simple rehydration therapy which could be easily incorporated into patient aftercare. 3. To ascertain if these metabolic changes can be prevented from developing post-operatively with a simple rehydration therapy which could be easily incorporated 4. Differences in health-related quality of life scores as assessed using SF-36 and FACIT- F questionnaires

—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 4, 2026