Skip to content

A multicentre trial to evaluate the use of serial carcinoembryonic antigen (CEA) assay as the prime indicator for second-look surgery in recurrent colorectal cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN76694943
Enrollment
Unknown
Registered
2001-07-01
Start date
1998-01-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon, rectum Cancer Colon, rectum

Interventions

All patients receive primary potentially curative surgery. Patients are randomised if a significant rise in serum CEA is detected to either: 1. Conventional Arm: Observation only. The patient is moni

Sponsors

Cancer Research UK (CRUK) (UK)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Aged 75 or under 2. Potentially curative resection performed for colorectal adenocarcinoma 3. No evidence of distant incurable spread (clinically or at surgery) 4. No evidence of hepatic, renal, pancreatic or infective disease 5. Willing to attend regular CEA monitoring in addition to clinical follow-up for 5 years

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration

Secondary

MeasureTime frame
Not provided at time of registration

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 8, 2026