General anxiety disorder Mental and Behavioural Disorders General anxiety disorder
Conditions
Interventions
Participants will complete a single test session, which will consist of the inhalation of air and the inhalation of 7.5% CO2, in counterbalanced order.
Sponsors
Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male and female participants 2. Aged 18-55 3. With a normal medical and psychiatric history, physical examination and ECG who give signed, fully-informed consent to participate
Exclusion criteria
Exclusion criteria: 1. Females who are pregnant, breastfeeding, or not using adequate contraception 2. Presence of any pathological condition 3. Personal history of current or past psychiatric illness by psychiatric interview 4. Strong family history of mood disorder, including panic disorder 5. Personal history of cardiovascular or respiratory disease, including asthma 6. Personal history of migraine headaches requiring treatment 7. Cigarette smoking in the last 6 months 8. Drinking more than the recommended units of alcohol per week 9. Personal history of alcoholism or drug dependence 10. Drinking more than 8 caffeinated drinks per day 11. Medication use (except local treatment, or aspirin or paracetamol) within 8 weeks of testing 12. Potential, in the opinion of the investigator, to be non-compliant with study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measures of processing of emotional information | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective measures of anxiety and cardiovascular function | — |
Countries
United Kingdom
Outcome results
None listed