Routine ventilator disconnection on critically ill patients - how bad is it? A clinical observational study in the intensive care unit at Uppsala University Hospital

Routinely ventilator disconnection on critically ill patients - effect on oxygenation and lung function. A clinical observational study in the intensive care unit at Uppsala University Hospital

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN76631800

Enrollment

Registered

2012-03-29

Start date

2011-02-14

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically ill patients with an acute respiratory failure treated with mechanically ventilation. Respiratory Respiratory failure, not elsewhere classified

Interventions

Twenty patients admitted to the intensive care unit will be consecutively enrolled in this clinical prospective observational study. The study is approved by the Regional Ethical Review Board in Uppsa

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with respiratory failure treated in the ICU with controlled mechanical ventilatory support 2. Need for fraction of inspired oxygen = 0.5 and positive end expiratory pressure = 10 cmH2O

Exclusion criteria

Exclusion criteria: 1. Patients with spontaneous mechanical ventilatory treatment, patients without an arterial access, 2. Patients without an informed consent from next of kin 3. Pregnant patients 4. Patients under the age of 18 5. Patients that do not meet the inclusion criteria

Design outcomes

Primary

Measure	Time frame
The difference in PaO2 (kPa) between baseline, 15 minutes and 60 minutes after the HEPA filter change.	—

Secondary

Measure	Time frame
The difference in pulmonary compliance between baseline, 15 minutes and 60 minutes after the HEPA filter change.	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026