Multiple Sclerosis Nervous System Diseases Multiple Sclerosis
Conditions
Interventions
Subjects are randomly assigned to one of four conditions (biased coin randomization):
1. Bicycle ergometry
2. Hand ergometry
3. Rowing
4. Waitlist control
The goal is to have 10 subjects in each gr
Sponsors
Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with secondary-progressive multiple sclerosis (MS) 2. Disease duration <20 years 3. Expanded disability status scale (EDSS) 4-6
Exclusion criteria
Exclusion criteria: 1. Immunomodulatory therapy in the last 3 months 2. Steroid therapy in the last 4 weeks 3. Relapsing-remitting or primary progressive MS 4. Laboratory markers of liver and kidney function outside of the normal range 5. Immunodeficiency or other serious medical illnesses (based on the judgement of the physician) 6. Hepatitis B or hepatitis C infection or other chronic liver diseases 7. Patients taking psychoactive medication (benzodiazepines, neuroleptics, antidepressants)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical fitness pre and post intervention as determined by a standardized ergometer test | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Walking ability (6-minute walk test) 2. Cognitive function (assessed by a neuropsychological battery including learning and memory, attention, executive function and processing speed) 3. Depression (IDS-30R) 4. Fatigue (MFIS) Assessed pre and post intervention. | — |
Countries
Germany
Outcome results
None listed