Magnetic resonance imaging (MRI) for abdominal aortic aneurysms to predict rupture or surgery: the MA3RS trial

Conditions

Abdominal Aortic Aneurysm Circulatory System Abdominal aortic aneurysm, ruptured

Forsythe RO, McBride OMB, Robson JMJ, Vesey AT, Winarski AC, Weston C, Debono S, Semple SI, Gray CD, MacGillivray TJ, Brittenden J, Roditi G, Stuart W, van Beek EJR, Tambyraja AL, Williams MC, Dweck MR, Newby DE.

2026-08-12

10.1093/bjs/znag100

Plasma Desmosine and Abdominal Aortic Aneurysm Disease

Ify Mordi, Rachael O. Forsythe, Corry Gellatly, Zaid Iskandar, Olivia McBride et al. (13 authors)

Journal of the American Heart Association2019-10-0939 citations

10.1161/jaha.119.013743

Magnetic resonance imaging using ultrasmall superparamagnetic particles of iron oxide for abdominal aortic aneurysm: a risk prediction study

Rachael O. Forsythe, Olivia McBride, J. M. Robson, Catriona Graham, Noel Conlisk et al. (8 authors)

Efficacy and Mechanism Evaluation2018-09-016 citations

10.3310/eme05040

18F-Sodium Fluoride Uptake in Abdominal Aortic Aneurysms: The SoFIA3 Study.

Forsythe RO, Dweck MR, McBride OMB, Vesey AT, Semple SI, Shah ASV, Adamson PD, Wallace WA, Kaczynski J, Ho W, van Beek EJR, Gray CD, Fletcher A, Lucatelli C, Marin A, Burns P, Tambyraja A, Chalmers RTA, Weir G, Mitchard N, Tavares A, Robson JMJ, Newby DE.

2018-02-01116 citations

10.1016/j.jacc.2017.11.053

Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair

David E. Newby, Rachael O. Forsythe, Olivia McBride, J. M. Robson, Alex Vesey et al. (47 authors)

Circulation2017-07-19174 citations

10.1161/circulationaha.117.028433

MRI using ultrasmall superparamagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair: MRI for abdominal aortic aneurysms to predict rupture or surgery—the MA3RS study

Olivia McBride, Colin Berry, Paul Burns, R.T.A. Chalmers, Barry J. Doyle et al. (22 authors)

Open Heart2015-04-0161 citations

10.1136/openhrt-2014-000190

Interventions

All patients will have a full formal and standardized clinical assessment at the first study visit that will include history, examination, documentation of cardiovascular risk factor profile (smoking

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Abdominal aortic aneurysms measuring =40 mm in anteroposterior diameter on ultrasound scanning 2. Age =40 years. Patients with abdominal aortic aneurysms less than 40 years may have a connective tissue disorder and a different aetiology to their disease

Exclusion criteria

Exclusion criteria: 1. Patients expected to, or already received, imminent elective or emergency surgical or endovascular repair 2. Contraindication to magnetic resonance imaging scanning identified from magnetic resonance imaging safety questionnaire 3. Patients refusing or unable to give informed consent 4. Woman with child-bearing potential and who are breastfeeding will not be enrolled into the trial (woman who have experienced menarche, are pre-menopausal, have not been sterilised or who are currently pregnant) 5. Intercurrent illness including patients with a systemic inflammatory disorder or underlying malignancy (life expectancy < 2 years) 6. Renal dysfunction (eGFR =30 mL/min/1.73m2) 7. Polycythemia 8. Contraindication to ferumoxytol (evidence of known iron overload, hemochromatosis, known hypersensitivity to ferumoxytol or its components or anaemia not caused by iron deficiency) 9. Contraindication to Iodine

Design outcomes

Primary

Measure	Time frame
The composite of aneurysm rupture or aortic aneurysm repair	—

Secondary

Measure	Time frame
1. The rate of aneurysm rupture 2. The rate of surgical repair of the aneurysm 3. Aneurysm growth rate 4. All-cause and aneurysm-related mortality 5. We will conduct exploratory analyses examining the interactions between mural USPIO uptake, biomechanical stress, clinical risk factors and serum biomarkers of extracellular matrix turnover and inflammation. Clinicians involved directly with patient surveillance and care will be blinded to the magnetic resonance imaging findings of mural USPIO uptake.	—

Measure

Time frame

1. The rate of aneurysm rupture 2. The rate of surgical repair of the aneurysm 3. Aneurysm growth rate 4. All-cause and aneurysm-related mortality 5. We will conduct exploratory analyses examining the interactions between mural USPIO uptake, biomechanical stress, clinical risk factors and serum biomarkers of extracellular matrix turnover and inflammation. Clinicians involved directly with patient surveillance and care will be blinded to the magnetic resonance imaging findings of mural USPIO uptake.

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Countries

United Kingdom

Outcome results

None listed