Randomised placebo controlled cross-over trial of topical opioids in the management of analgesia in leg ulcers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN76288165

Enrollment

Registered

2003-09-12

Start date

2003-06-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Signs and Symptoms: Pain Skin and Connective Tissue Diseases Other disorders of skin and subcutaneous tissue, not elsewhere classified

Interventions

Prospective randomised controlled cross-over trial with questionnaire and interviews. Topical opioids versus placebo.

Eligibility

Inclusion criteria

Inclusion criteria: 20 Patients with chronic painful leg ulcers, from all inpatients at the Walsgrave Hospital (powered to give 75-80% preference rate of either active or placebo gel).

Exclusion criteria

Exclusion criteria: Does not match inclusion criteria

Design outcomes

Primary

Measure	Time frame
PRN (pro re nata - as needed) and regular analgesia requirement over preceding 24 h. Daily pain score and questionnaire regarding side-effects.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026