Cardiovascular disease Circulatory System
Conditions
Interventions
Fish oil capsules vs placebo
Sponsors
Nutricia Research Foundation (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age 21-65 years old Criteria for selection of an at-risk population (1 or more of the following): 1. Total cholesterol : > 5.2 mmol/l but 130 mmHg but 80 mmHg but 102 cm male or > 84 cm female 6. Family history of cardiovascular disease
Exclusion criteria
Exclusion criteria: Diabetes; previous stroke, myocardial infarction or angina, renal; bowel or liver disease; hormonal abnormalities; medication for high blood pressure, high blood fats, inflammatory conditions or depression; consuming large amounts of oily fish; taking dietary supplements; breastfeeding; excessive alcohol consumption.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular reactivity (using EndoPAT), numbers of endothelial progenitor cells and endothelial and platelet micro particles. All outcome measures to be assessed at baseline and after 8 weeks intervention on each arm of the crossover study (i.e. Week 0, week 8, week 16 and week 24). Outcomes as follows: Arterial function assessed by EndoPAT Nitric oxide by nitric oxide analyzer Endothelial progenitor cells and microparticles by flow cytometry Circulating markers of inflammation and vascular function by ELISA Fatty acid composition of plasma by gas chromatography | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood lipids, glucose, insulin, inflammatory markers, nitric oxide, dietary intake. All outcome measures to be assessed at baseline and after 8 weeks intervention on each arm of the crossover study (i.e. Week 0, week 8, week 16 and week 24. | — |
Countries
United Kingdom
Outcome results
None listed