Depressive symptoms in patients with coronary artery disease Mental and Behavioural Disorders Depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Amended as of 24/01/2011: 1. Gender: both 2. Minimum age: 18, maximum age: 75 3. Patients with any manifestation of coronary heart disease with recent (less than 3 months old) coronary angiograms and elevated questionnaire scores for depression (Hospital Anxiety and Depression Scale [HADS] depression subscale greater than or equal to 8) Initial information at time of registration: 1. Gender: both 2. Minimum age: 18, maximum age: 75 3. Patients hospitalised for any manifestation of coronary heart disease with recent (less than 3 months old) coronary angiograms and elevated questionnaire scores for depression (Hospital Anxiety and Depression Scale [HADS] depression subscale greater than or equal to 8)
Exclusion criteria
Exclusion criteria: 1. Severe heart failure or other acutely life-threatening conditions 2. Severe chronic inflammatory disease 3. Current suicidal tendency 4. Severe depressive episode or other severe mental illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amended as of 24/01/2011: Changes from baseline to 18 months in depressive symptoms (HADS-D) Initial information at time of registration: Changes from baseline to year 1 in depressive symptoms (HADS-D) | — |
Secondary
| Measure | Time frame |
|---|---|
| Amended as of 24/01/2011: The following will be monitored up to 24 months: 1. Remission of depressive disorder (Structured Clinical Interview [SCID]) at baseline and 18 months 2. Type D pattern, assessed by a self rating questionnaire (DS-14) at baseline, 1, 6, 12, 18 and 24 months 3. Health-related quality of life, evaluated by the self rating questionnaires the 36-item Short Form health survey (SF-36) and EuroQuol-5D at baseline, 6, 12, 18 and 24 months 4. Cardiovascular risk profile 5. Neuroendocrine and immunological activation 6. Coagulation 7. Heart rate variability 8. Cardiac events 9. Health care utilisation and costs Initial information at time of registration: The following will be monitored up to 24 months: 1. Remission of depressive disorder (Structured Clinical Interview [SCID]) at baseline and 12 months 2. Type D pattern, assessed by a self rating questionnaire (DS-14) at baseline, 1, 6, 12, and 24 months 3. Health-related quality of life, evaluated by the self rating questionnaires the 36-item Short Form health survey (SF-36) and EuroQuol-5D at baseline, 6, 12, and 24 months 4. Cardiovascular risk profile 5. Neuroendocrine and immunological activation 6. Coagulation 7. Heart rate variability 8. Cardiac events 9. Health care utilisation and costs | — |
Countries
Germany