A pilot study of a new test to predict extubation failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN76206152

Enrollment

152

Registered

2008-12-04

Start date

2004-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory failure Respiratory Respiratory failure, not elsewhere classified

Interventions

This is a non-randomised, single-arm, pilot study of the dead space addition (DSA) test which aims to detect increased risk of extubation failure. DSA test procedure: The DSA test consisted of addi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Both males and females, aged 18 or older 2. Improvement of the underlying cause of acute respiratory failure 3. Patients who fulfilled the criteria for extubation recommended by the Consensus Conference on Weaning after the 120-minute spontaneous breathing test: no signs of respiratory insufficiency (paradoxical breathing, abdominal breathing, agitation, excessive sweating, etc.), saturation of oxygen in arterial blood flow (SpO2) >90%, FiO2 60 mmHg, fraction of inspired oxygen (FiO2) 13 6. Body temperature <38ºC 7. No need for vasoactive or sedative drugs

Exclusion criteria

Exclusion criteria: Tracheostomised patients

Design outcomes

Primary

Measure	Time frame
Clinical signs of increased work of breathing (intercostal retractions, accessory muscle use, nasal flaring) were monitored during the DSA test.	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026