Prevention of venous thromboembolism after hip fracture surgery Circulatory System
Conditions
Interventions
The patients were divided into the aspirin group and rivaroxaban group according to odd or even number of the end of the registration number. All patients were given enoxaparin subcutaneous injection
Sponsors
Department of Orthopedic Surgery, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hip fracture who were diagnosed by X-ray and/or computed tomography.
Exclusion criteria
Exclusion criteria: 1. Lower extremity DVT confirmed by preoperative ultrasonography 2. History of thromboembolic disease and undergoing anticoagulant therapy 3. Presence of hemorrhagic diseases and/or a major bleeding history 4. Severe liver or kidney diseases 5. Coagulation disorders 6. Allergy to enoxaparin, aspirin, or rivaroxaban 7. Platelet count less than 100*10^9 cells/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Adjudicated venous thromboembolism, which was defined as deep vein thrombosis involving the inferior vena cava to popliteal vein or pulmonary embolism. Ultrasonography of the lower extremity vein is a routine examination. All patients had to be examined before and after surgery. Pulmonary embolism was confirmed by computed tomographic pulmonary angiography, when the patient's symptoms are suspected to be a pulmonary embolism. 2. The primary safety outcome was bleeding, including major or clinically relevant nonmajor bleeding, according to Anderson’s criteria. Patients were followed for 90 days regarding venous thromboembolism and bleeding complications. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of health issues in the 90 days following the intervention: 1. Death 2. Myocardial infarction 3. Stroke 4. Wound infection. | — |
Countries
China
Contacts
Public ContactQiang Huang
Outcome results
None listed