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Psychotherapy study to examine whether exposure-based psychotherapy for anxiety disorders is particularly effective when endogenous cortisol levels are high

Randomised controlled trial to determine whether the effectiveness of exposure-based psychotherapy for specific phobia is influenced by endogenous cortisol levels

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN76072597
Enrollment
60
Registered
2013-04-08
Start date
2011-06-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Specific Phobia (Spider Phobia) / Psychotherapy Mental and Behavioural Disorders Specific (isolated) phobias

Interventions

Comparing two treatment conditions for spider phobia. Participants underwent a one session (three hour) exposure therapy treatment. Participants were gradually exposed to different living spiders of

Sponsors

University of Saarland (Germany)
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Participation is restricted to: 1. Healthy, non-smoking women, aged 18-60 2. Using oral contraceptives 3. Body mass index between 20-25 mg²

Exclusion criteria

Exclusion criteria: 1. Recent history of systemic or oral cortisol therapy 2. Any axis I disorder (other than spider phobia) 3. Severe acute or chronic disease (e.g. lung or heart diseases) 4. Allergic reactions to insect bites 5. Pregnancy and lactating 5. Current pharmacological treatment or psychotherapy 6. We also require patients to refrain from physical exercise, alcohol and caffeinated drinks within 3 hours prior to therapy

Design outcomes

Primary

MeasureTime frame
Behavioural Approach Test (BAT): To test the patients? fear and avoidance of living spiders participants are asked to approach a living house spider that is placed in a sealed container. The patient?s behaviour is rated on a scale from 0 to 12, where 0: refusal to enter the room and 12: holding the spider for at least 20 seconds. Measured at baseline (prior to treatment), one week after treatment, and three months (12-14 weeks after treatment).

Secondary

MeasureTime frame
Fear of Spider Questionnaire (FSQ): The FSQ is a self-report questionnaire designed to measure spider phobia. It consists of 18 items that refer to a restricted time period and are rated on a seven point scale. Measured at baseline (prior to treatment), one week after treatment, and three months (12-14 weeks after treatment).

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026