Topic: Cancer
Conditions
Interventions
Cannula inserted into each arm for the administration of the radioactive material and the taking of blood samples.
Sponsors
King's College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years 2. Women of childbearing potential must have documented negative pregnancy test on day 1, prior to (18F)BF4-administration 3. Diagnosis of a malignancy of the thyroid or a malignancy of a salivary gland 4. All patients have to be suitable for surgical treatment as part of their normal management 5. Able to comply with treatment plans, scheduled visits, all study PET imaging and follow-up 6. Willing to give informed consent 7. Not be taking thyroid mediciation or iodine containing medication
Exclusion criteria
Exclusion criteria: 1. Previous ionising radiation exposure for research purposes or exposure to any previous experimental medicine that might affect the uptake of BF4 would exclude the patient from this ionising radiation study 2. Patients without adequate understanding of written or spoken English would not be able to participate in this study as translation of the patient information sheet will not be possible 3. Any prior treatment for the thyroid or salivary gland tumours 4. Pregnancy or lactation 5. Any other problems that may make the patient unable to tolerate the PET scans or translational biopsies 6. Ingestion of iodine containing medication (eg amiodarone) within preceding 12 months, administration of iv contrast media within 6 months or thyroid hormones within 2 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the biodistribution of [18F]tetrafluoroborate in vivo | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
England, United Kingdom
Outcome results
None listed