An open randomised comparison of Gatifloxacin versus Cefixime for the treatment of uncomplicated enteric fever

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN75784880

Enrollment

169

Registered

2005-07-22

Start date

2005-06-02

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enteric fever Infections and Infestations Enteric fever

Interventions

Open label randomised controlled trial of gatifloxacin versus cefixime. Please note that due to safety reasons this trial was terminated on the 8th September 2005.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The treating physician believes the diagnosis to be enteric fever 2. More than or equal to three days history of fever, headache and oral temperature more than or equal to 37.8 °C

Exclusion criteria

Exclusion criteria: 1. Complicated typhoid (jaundice, shock, peritonism, gastrointestinal bleeding, myocarditis, encephalopathy) 2. Pregnancy 3. Lactation 4. Allergy to study drug 5. Quinolone, fluoroquinolone, macrolide or 3rd generation cephalosporin treatment within previous week 6. Unable to take oral medication

Design outcomes

Primary

Measure	Time frame
Time to fever clearance	—

Secondary

Measure	Time frame
1. Development of complications 2. Blood culture sterilisation 3. Eradication of stool carriage 4. Need for retreatment 5. Development of enteric fever in household contacts 6. Treatment failure	—

Countries

Nepal

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 7, 2026