Diabetes Nutritional, Metabolic, Endocrine Diabetes
Conditions
Interventions
Diet/insulin/sulphonylurea/metformin in preventing the complications of type 2 diabetes.
Sponsors
Medical Research Council (MRC) (UK)
University of Oxford Diabetes Trials Unit
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed type 2 diabetic patients 2. Aged 25 - 65 years inclusive (median age 52 years) 3. Two fasting plasma glucose concentrations more than 6 mmol/l
Exclusion criteria
Exclusion criteria: 1. Severe vascular disease 2. Accelerated hypertension 3. Proliferative or pre-proliferative retinopathy 4. Renal failure 5. Other life threatening diseases an illness requiring systematic steroids 6. An occupation that precluded insulin therapy 7. Language difficulties 8. Ketouric greater than 3 millimols per litre suggestive of insulin dependent diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Diabetes-related mortality: deaths from heart attacks, sudden death, stroke, complications from peripheral vascular disease or amputations, renal failure, hyperglycaemic or hypoglycaemic coma. 2. Total mortality 3. Diabetes-related mortality and major clinical endpoints, including non-fatal myocardial infarct, clinical angina with confirmatory abnormal ECG, heart failure, major stroke, retinal photocoagulation, vitreous haemorrhage, blindness, renal failure | — |
Secondary
| Measure | Time frame |
|---|---|
| Added 15/08/2008: 1. Quality of life 2. Health economic outcomes 3. Cognitive function | — |
Countries
England, United Kingdom
Outcome results
None listed